ChloroquineV1, France, Analysis, bibRecord, 000232

Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems.

Identifieur interne : 000232 ( France/Analysis ); précédent : 000231; suivant : 000233

Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems.

Auteurs : N. Berthault [France] ; Benoit Maury [France] ; C. Agrario [France] ; A. Herbette [France] ; J.-S. Sun [France] ; Nadine Peyriéras [France] ; Marie Dutreix [France]

Source :

Cancer Gene Therapy [ 0929-1903 ] ; 2011-10.

RBID : Hal:hal-00683650

Abstract

Introducing small DNA molecules (Dbait) impairs the repair of damaged chromosomes and provides a new method for enhancing the efficiency of radiotherapy in radio-resistant tumors. The radiosensitizing activity is dependent upon the efficient delivery of Dbait molecules into the tumor cells. Different strategies have been compared, to improve this key step. We developed a pipeline of assays to select the most efficient nanoparticles and administration protocols before preclinical assays: (i) molecular analyses of complexes formed with Dbait molecules, (ii) cellular tests for Dbait uptake and activity, (iii) live zebrafish embryo confocal microscopy monitoring for in vivo distribution and biological activity of the nanoparticles and (iv) tumor growth and survival measurement on mice with xenografted tumors. Two classes of nanoparticles were compared, polycationic polymers with linear or branched polyethylenimine (PEI) and covalently attached cholesterol (coDbait). The most efficient Dbait transfection was observed with linear PEI complexes, in vitro and in vivo. Doses of coDbait ten-fold higher than PEI/Dbait nanoparticles, and pretreatment with chloroquine, were required to obtain the same antitumoral effect on xenografted melanoma. However, with a 22-fold lower 'efficacy dose/toxicity dose' ratio as compared with Dbait/PEI, coDbait was selected for clinical trials.

Url:

https://hal.archives-ouvertes.fr/hal-00683650

DOI: 10.1038/cgt.2011.39

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000054
to stream Hal, to step Curation: 000054
to stream Hal, to step Checkpoint: 000166
to stream Main, to step Merge: 001460
to stream Main, to step Curation: 001458
to stream Main, to step Exploration: 001458
to stream France, to step Extraction: 000232

Links to Exploration step

Hal:hal-00683650

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Introducing small DNA molecules (Dbait) impairs the repair of damaged chromosomes and provides a new method for enhancing the efficiency of radiotherapy in radio-resistant tumors. The radiosensitizing activity is dependent upon the efficient delivery of Dbait molecules into the tumor cells. Different strategies have been compared, to improve this key step. We developed a pipeline of assays to select the most efficient nanoparticles and administration protocols before preclinical assays: (i) molecular analyses of complexes formed with Dbait molecules, (ii) cellular tests for Dbait uptake and activity, (iii) live zebrafish embryo confocal microscopy monitoring for in vivo distribution and biological activity of the nanoparticles and (iv) tumor growth and survival measurement on mice with xenografted tumors. Two classes of nanoparticles were compared, polycationic polymers with linear or branched polyethylenimine (PEI) and covalently attached cholesterol (coDbait). The most efficient Dbait transfection was observed with linear PEI complexes, in vitro and in vivo. Doses of coDbait ten-fold higher than PEI/Dbait nanoparticles, and pretreatment with chloroquine, were required to obtain the same antitumoral effect on xenografted melanoma. However, with a 22-fold lower 'efficacy dose/toxicity dose' ratio as compared with Dbait/PEI, coDbait was selected for clinical trials.</p>
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<name sortKey="Dutreix, Marie" sort="Dutreix, Marie" uniqKey="Dutreix M" first="Marie" last="Dutreix">Marie Dutreix</name>
<name sortKey="Herbette, A" sort="Herbette, A" uniqKey="Herbette A" first="A." last="Herbette">A. Herbette</name>
<name sortKey="Maury, Benoit" sort="Maury, Benoit" uniqKey="Maury B" first="Benoit" last="Maury">Benoit Maury</name>
<name sortKey="Peyrieras, Nadine" sort="Peyrieras, Nadine" uniqKey="Peyrieras N" first="Nadine" last="Peyriéras">Nadine Peyriéras</name>
<name sortKey="Sun, J S" sort="Sun, J S" uniqKey="Sun J" first="J.-S." last="Sun">J.-S. Sun</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems.
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	Serveur d'exploration Chloroquine
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Serveur d'exploration Chloroquine

Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems.

Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems.

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